Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC4711849 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Xu Xiaojun X Yu Tao T Chen Shi-Jie SJ
Proceedings of the National Academy of Sciences of the United States of America 20151222 1
RNA functions are intrinsically tied to folding kinetics. The most elementary step in RNA folding is the closing and opening of a base pair. Understanding this elementary rate process is the basis for RNA folding kinetics studies. Previous studies mostly focused on the unfolding of base pairs. Here, based on a hybrid approach, we investigate the folding process at level of single base pairing/stacking. The study, which integrates molecular dynamics simulation, kinetic Monte Carlo simulation, and ...[more]