Ontology highlight
ABSTRACT:
SUBMITTER: Sanjiv K
PROVIDER: S-EPMC4713868 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Sanjiv Kumar K Hagenkort Anna A Calderón-Montaño José Manuel JM Koolmeister Tobias T Reaper Philip M PM Mortusewicz Oliver O Jacques Sylvain A SA Kuiper Raoul V RV Schultz Niklas N Scobie Martin M Charlton Peter A PA Pollard John R JR Berglund Ulrika Warpman UW Altun Mikael M Helleday Thomas T
Cell reports 20151231 2
ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that replication stress induced by the CHK1 inhibitor AZD7762 results in replication catastrophe and apoptosis, when combined with the ATR inhibitor VE-821 specifically in cancer cells. Combined treatment w ...[more]