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Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins.

ABSTRACT: We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investigated by their cellular uptake in HeLa cells by TP confocal microscopy.

SUBMITTER: Yadav P

PROVIDER: S-EPMC4721820 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins.

Yadav Preeti P Gill Hardeep Singh HS Chand Karam K Li Lian L Kumar Jayant J Sharma Sunil K SK

Sensors (Basel, Switzerland) 20151219 12

We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investiga ...[more]

PMID: 26703600

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