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Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models.

ABSTRACT: Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.

SUBMITTER: Miquel S 

PROVIDER: S-EPMC4726104 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models.

Miquel S S   Martín R R   Lashermes A A   Gillet M M   Meleine M M   Gelot A A   Eschalier A A   Ardid D D   Bermúdez-Humarán L G LG   Sokol H H   Thomas M M   Theodorou V V   Langella P P   Carvalho F A FA  

Scientific reports 20160118

Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, signi  ...[more]