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Cell Proliferation in Neuroblastoma.


ABSTRACT: Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a dismal prognosis for children diagnosed with advanced stage or relapsed disease. This review focuses upon factors responsible for cell proliferation in neuroblastoma including transcription factors, kinases, and regulators of the cell cycle. Novel therapeutic strategies directed toward these targets in neuroblastoma are discussed.

SUBMITTER: Stafman LL 

PROVIDER: S-EPMC4728460 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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Cell Proliferation in Neuroblastoma.

Stafman Laura L LL   Beierle Elizabeth A EA  

Cancers 20160112 1


Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a dismal prognosis for children diagnosed with advanced stage or relapsed disease. This review focuses upon factors responsible for cell proliferation in neuroblastoma including transcription factors, kinases, and regulators of the cell cycle. Novel therapeutic strategies directed toward these targets in neuroblastoma are discussed. ...[more]

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