Ontology highlight
ABSTRACT:
SUBMITTER: Jain A
PROVIDER: S-EPMC4729824 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Jain Abhishek A Graveline Amanda A Waterhouse Anna A Vernet Andyna A Flaumenhaft Robert R Ingber Donald E DE
Nature communications 20160106
Accurate assessment of blood haemostasis is essential for the management of patients who use extracorporeal devices, receive anticoagulation therapy or experience coagulopathies. However, current monitoring devices do not measure effects of haemodynamic forces that contribute significantly to platelet function and thrombus formation. Here we describe a microfluidic device that mimics a network of stenosed arteriolar vessels, permitting evaluation of blood clotting within small sample volumes und ...[more]