Ontology highlight
ABSTRACT:
SUBMITTER: Yu C
PROVIDER: S-EPMC4731815 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Yu Chuanfei C Gao Kai K Zhu Lei L Wang Wenbo W Wang Lan L Zhang Feng F Liu Chunyu C Li Meng M Wormald Mark R MR Rudd Pauline M PM Wang Junzhi J
Scientific reports 20160129
Two non-human glycan epitopes, galactose-α-1,3-galactose (α-gal) and Neu5Gc-α-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while α-gal attached to Fc glycans was not. However, the antigenicity of Neu5Gc on the Fc glycans remains unclear in the context that most mAbs carry only Fc glycans. After studying two clinical mAbs carrying significant amounts of Fc Neu5Gc, we show that their binding activity with anti-Neu5Gc ...[more]