Ontology highlight
ABSTRACT:
SUBMITTER: Sheng J
PROVIDER: S-EPMC4731819 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Sheng Jin J Fang Wenfeng W Yu Juan J Chen Nan N Zhan Jianhua J Ma Yuxiang Y Yang Yunpeng Y Huang Yan Y Zhao Hongyun H Zhang Li L
Scientific reports 20160129
The effects of treatments to programmed death ligand-1 (PD-L1) expression is unknown. The aim of this study was to investigate the impact of neoadjuvant chemotherapy (NACT) on PD-L1 expression in non-small cell lung cancer (NSCLC) patients. PD-L1 expression was detected by immunohistochemistry (IHC) method in 32 paired tumor specimens pre and post-NACT. The positivity of PD-L1 on tumor cells (TCs) changed from 75% to 37.5% after NACT (p = 0.003). Cases with IHC score of 1, 2, 3 all underwent app ...[more]