Ontology highlight
ABSTRACT:
SUBMITTER: Testoni E
PROVIDER: S-EPMC4734836 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Testoni Ewelina E Stephenson Natalie L NL Torres-Ayuso Pedro P Marusiak Anna A AA Trotter Eleanor W EW Hudson Andrew A Hodgkinson Cassandra L CL Morrow Christopher J CJ Dive Caroline C Brognard John J
EMBO molecular medicine 20160201 2
The lack of actionable mutations in patients with non-small cell lung cancer (NSCLC) presents a significant hurdle in the design of targeted therapies for this disease. Here, we identify somatically mutated ABL1 as a genetic dependency that is required to maintain NSCLC cell survival. We demonstrate that NSCLC cells with ABL1 mutations are sensitive to ABL inhibitors and we verify that the drug-induced effects on cell viability are specific to pharmacological inhibition of the ABL1 kinase. Furth ...[more]