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Total Synthesis of the Resveratrol Oligomers (±)‐Ampelopsin B and (±)‐ϵ‐Viniferin.

ABSTRACT: AbstractThe total synthesis of the resveratrol dimers (±)‐ampelopsin B and (±)‐ϵ‐viniferin is reported. Highlights of the approach include the use of cyclopropylmethyl groups to protect aromatic alcohols. This group allows an acid promoted three‐step, one‐pot deprotection–epimerization–cyclization of an advanced intermediate to give (±)‐ampelopsin B. An important advantage with our strategy is the possibility of synthesizing analogs to these natural products to further study the chemistry and biology of resveratrol oligomers.

SUBMITTER: Lindgren AEG

PROVIDER: S-EPMC4737285 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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Publisher Correction: Computation-guided asymmetric total syntheses of resveratrol dimers.

Project description: Not available

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