Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4741855 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Wang Yufeng Y Kuramitsu Yasuhiro Y Baron Byron B Kitagawa Takao T Tokuda Kazuhiro K Akada Junko J Nakamura Kazuyuki K
Oncotarget 20151101 37
Microtubule-associated protein 1A/1B-light chain 3 (LC3)-II is essential for autophagosome formation and is widely used to monitor autophagic activity. We show that CGK733 induces LC3 II and LC3-puncta accumulation, which are not involved in the activation of autophagy. The treatment of CGK733 did not alter the autophagic flux and was unrelated to p62 degradation. Treatment with CGK733 activated the AMP-activated protein kinase (AMPK) and protein kinase RNA-like endoplasmic reticulum kinase/CCAA ...[more]