Ontology highlight
ABSTRACT:
SUBMITTER: Qin W
PROVIDER: S-EPMC4741864 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Qin Wenjie W Li Chao C Zheng Wen W Guo Qingqu Q Zhang Yuefeng Y Kang Muxing M Zhang Bo B Yang Bin B Li Baozhong B Yang Haijun H Wu Yulian Y
Oncotarget 20151101 37
Autophagy defect has been shown to be correlated with malignant phenotype and poor prognosis of human cancers, however, the detailed mechanisms remain obscure. In this study, we investigated the biological changes induced by autophagy inhibition in gastric cancer. We showed that inhibition of autophagy in gastric cancer cells promotes epithelial-mesenchymal transition (EMT) and metastasis, alters metabolic phenotype from mitochondrial oxidative phosphorylation to aerobic glycolysis and converts ...[more]