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Bone marrow micrometastases in early breast cancer-30-year outcome.


ABSTRACT: Micrometastases in bone marrow of women with early breast cancer were first identified immunocytochemically in the 1980s. We report on the original cohort of women with a median follow-up of 30 years.In total, 350 women with primary breast cancer had eight bone marrow aspirates examined with antibody to epithelial membrane antigen. Data on long-term mortality were obtained via record linkage to death certification.At a 30-year median follow-up, 79 out of 89 (89%) patients with micrometastases have died compared with 202 out of 261 (77%) without (hazard ratio=1.46 (95% CI 1.12-1.90), P=0.0043). Most marked effect of micrometastases on overall survival (OS) was seen in patients aged ? 50 at surgery (N=97, P=0.012), and on all patients within 10 years of diagnosis. In multivariable analyses, the presence of micrometastases was no longer a statistically significant prognostic factor.Bone marrow micrometastases are predictive for OS, particularly in the first decade and in younger patients.

SUBMITTER: Mansi J 

PROVIDER: S-EPMC4742582 | biostudies-other | 2016 Feb

REPOSITORIES: biostudies-other

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Bone marrow micrometastases in early breast cancer-30-year outcome.

Mansi J J   Morden J J   Bliss J M JM   Neville M M   Coombes R C RC  

British journal of cancer 20160114 3


<h4>Background</h4>Micrometastases in bone marrow of women with early breast cancer were first identified immunocytochemically in the 1980s. We report on the original cohort of women with a median follow-up of 30 years.<h4>Patients and methods</h4>In total, 350 women with primary breast cancer had eight bone marrow aspirates examined with antibody to epithelial membrane antigen. Data on long-term mortality were obtained via record linkage to death certification.<h4>Results</h4>At a 30-year media  ...[more]

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