Ontology highlight
ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC4747392 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Liu Baocai B Su Yu Y Li Ting T Yuan Wanqiong W Mo Xiaoning X Li Henan H He Qihua Q Ma Dalong D Han Wenling W
Oncotarget 20151201 38
The dysregulation of epidermal growth factor receptor (EGFR) signaling has been well documented to contribute to the progression of non-small cell lung cancer (NSCLC), the leading cause of cancer death in the world. EGF-stimulated EGFR activation induces receptor internalization and degradation, which plays an important role in EGFR signaling. This process is frequently deregulated in cancer cells, leading to enhanced EGFR levels and signaling. Our previous study on CMTM7 is only limited to a br ...[more]