Ontology highlight
ABSTRACT:
SUBMITTER: Chen R
PROVIDER: S-EPMC47482 | biostudies-other | 1993 Oct
REPOSITORIES: biostudies-other
Chen R R Lewis K A KA Perrin M H MH Vale W W WW
Proceedings of the National Academy of Sciences of the United States of America 19931001 19
Corticotropin-releasing factor (CRF) is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. We report here the cloning of a cDNA coding for a CRF receptor from a human corticotropic tumor library. The cloned cDNA encodes a 415-amino acid protein comprising seven putative membrane-spanning domains and is structurally related to the calcitonin/va ...[more]