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The role of piRNA and its potential clinical implications in cancer.

ABSTRACT: Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed.

SUBMITTER: Assumpcao CB

PROVIDER: S-EPMC4750480 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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The role of piRNA and its potential clinical implications in cancer.

Assumpção Carolina Baraúna CB Calcagno Danielle Queiroz DQ Araújo Taíssa Maíra Thomaz TM Santos Sidney Emmanuel Batista dos SE Santos Ândrea Kely Campos Ribeiro dos ÂK Riggins Gregory Joseph GJ Burbano Rommel Rodriguez RR Assumpção Paulo Pimentel PP

Epigenomics 20150501 6

Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules h ...[more]

PMID: 25929784

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