Ontology highlight
ABSTRACT:
SUBMITTER: Coughlin P
PROVIDER: S-EPMC47579 | biostudies-other | 1993 Oct
REPOSITORIES: biostudies-other
Coughlin P P Sun J J Cerruti L L Salem H H HH Bird P P
Proceedings of the National Academy of Sciences of the United States of America 19931001 20
We describe a cDNA encoding a serine proteinase inhibitor present in placental tissue and the cytosolic fraction of K562 cells. On the basis of its interaction with thrombin, through which it was discovered, the inhibitor has been operationally named the placental thrombin inhibitor (PTI). Amino acid sequence comparisons suggest that its reactive center is located at Arg-341 and Cys-342, that it lacks a classical N-terminal signal sequence, and that it has the highest degree of similarity to int ...[more]