Ontology highlight
ABSTRACT:
SUBMITTER: Mertz KD
PROVIDER: S-EPMC4760343 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Mertz Kirsten D KD Mager Lukas F LF Wasmer Marie-Hélène MH Thiesler Thore T Koelzer Viktor H VH Ruzzante Giulia G Joller Stefanie S Murdoch Jenna R JR Brümmendorf Thomas T Genitsch Vera V Lugli Alessandro A Cathomas Gieri G Moch Holger H Weber Achim A Zlobec Inti I Junt Tobias T Krebs Philippe P
Oncoimmunology 20150626 1
Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays a role in intestinal inflammation, yet its contribution to the pathogenesis of CRC is unknown. Using immunohistochemistry on 713 resected human CRC specimens, we show here that IL-33 and its receptor ST2 are expressed in low-grade and early-stage huma ...[more]