Ontology highlight
ABSTRACT:
SUBMITTER: Nakajima K
PROVIDER: S-EPMC47615 | biostudies-other | 1993 Oct
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19931001 20
In the biosynthetic pathway of tropane alkaloids, tropinone reductase (EC 1.1.1.236) (TR)-I and TR-II, respectively, reduce a common substrate, tropinone, stereospecifically to the stereoisomeric alkamines tropine and pseudotropine (psi-tropine). cDNA clones coding for TR-I and TR-II, as well as a structurally related cDNA clone with an unknown function, were isolated from the solanaceous plant Datura stramonium. The cDNA clones for TR-I and TR-II encode polypeptides containing 273 and 260 amino ...[more]