Ontology highlight
ABSTRACT:
SUBMITTER: Josephs DH
PROVIDER: S-EPMC4762492 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Josephs Debra H DH Sarker Debashis D
Translational oncogenomics 20150101 Suppl 1
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is integral to many essential cell processes, including cell growth, differentiation, proliferation, motility, and metabolism. Somatic mutations and genetic amplifications that result in activation of the pathway are frequently detected in cancer. This has led to the development of rationally designed therapeutics targeting key members of the pathway. Critical to the successful development of these drugs are pharmacodynamic biomarkers th ...[more]