Ontology highlight
ABSTRACT:
SUBMITTER: Steger M
PROVIDER: S-EPMC4769169 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
eLife 20160129
Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the most common amino acid substitution activates the kinase two- to threefold. This has motivated the development of LRRK2 kinase inhibitors; however, poor consensus on physiological LRRK2 substrates has hampered clinical development of such therapeutics. We employ a combination of phosphoproteomics, genetics, and pharmacology ...[more]