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Current Issues in the Diagnosis and Treatment of Endometrial Carcinoma.

ABSTRACT: Endometrial carcinoma is the most common carcinoma of the female genital tract. Its most important clinical sign is postmenopausal bleeding. An endometrial biopsy is essential for diagnosis. Treatment decisions are governed by tumour risk assessment and patient comorbidity, which is often present. Pelvic and paraaortic lymph node dissection is unnecessary in low risk cases (definition: pT1?a, G1/2) and adjuvant radiotherapy and systemic treatments are usually avoidable. Treatment of high-risk patients (G3 and/or pT1b) and palliative cases is difficult and not well standardised. New molecular-based subtype classification may help treatment decision making in future.

SUBMITTER: Stubert J

PROVIDER: S-EPMC4771503 | biostudies-other | 2016 Feb

REPOSITORIES: biostudies-other

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Current Issues in the Diagnosis and Treatment of Endometrial Carcinoma.

Stubert J J Gerber B B

Geburtshilfe und Frauenheilkunde 20160201 2

Endometrial carcinoma is the most common carcinoma of the female genital tract. Its most important clinical sign is postmenopausal bleeding. An endometrial biopsy is essential for diagnosis. Treatment decisions are governed by tumour risk assessment and patient comorbidity, which is often present. Pelvic and paraaortic lymph node dissection is unnecessary in low risk cases (definition: pT1 a, G1/2) and adjuvant radiotherapy and systemic treatments are usually avoidable. Treatment of high-risk pa ...[more]

PMID: 26941450

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