Ontology highlight
ABSTRACT:
SUBMITTER: Holloway AK
PROVIDER: S-EPMC4776709 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Holloway Alisha K AK Bruneau Benoit G BG Sukonnik Tatyana T Rubenstein John L JL Pollard Katherine S KS
Molecular biology and evolution 20151229 4
Mammals have evolved remarkably different sensory, reproductive, metabolic, and skeletal systems. To explore the genetic basis for these differences, we developed a comparative genomics approach to scan whole-genome multiple sequence alignments to identify regions that evolved rapidly in an ancestral lineage but are conserved within extant species. This pattern suggests that ancestral changes in function were maintained in descendants. After applying this test to therian mammals, we identified 4 ...[more]