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Nanomedicines for Endothelial Disorders.

ABSTRACT: The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.

SUBMITTER: Chung BL

PROVIDER: S-EPMC4778260 | biostudies-other | 2015 Dec

REPOSITORIES: biostudies-other

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Nanomedicines for Endothelial Disorders.

Chung Bomy Lee BL Toth Michael J MJ Kamaly Nazila N Sei Yoshitaka J YJ Becraft Jacob J Mulder Willem J M WJ Fayad Zahi A ZA Farokhzad Omid C OC Kim YongTae Y Langer Robert R

Nano today 20151201 6

The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents ...[more]

PMID: 26955397

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