Ontology highlight
ABSTRACT:
SUBMITTER: Leroueil PR
PROVIDER: S-EPMC4779365 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
The journal of physical chemistry. B 20150814 35
Atomic force microscopy force-pulling experiments have been used to measure the binding forces between folic acid (FA) conjugated poly(amidoamine) (PAMAM) dendrimers and folate binding protein (FBP). The generation 5 (G5) PAMAM conjugates contained an average of 2.7, 4.7, and 7.2 FA per dendrimer. The most probable rupture force was measured to be 83, 201, and 189 pN for G5-FA2.7, G5-FA4.7, and G5-FA7.2, respectively. Folic acid blocking experiments for G5-FA7.2 reduced the frequency of successf ...[more]