Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.
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ABSTRACT:
SUBMITTER: Fannin RD
PROVIDER: S-EPMC4785037 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
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Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.
Fannin R D RD Gerrish K K Sieber S O SO Bushel P R PR Watkins P B PB Paules R S RS
Clinical pharmacology and therapeutics 20160222 4
The diagnosis of drug-induced liver injury is hindered by the limited utility of clinical chemistries. We have shown that hepatotoxicants can produce peripheral blood transcriptome "signatures" (PBTS) in rodents and humans. In this study, 42 adults were treated with acetaminophen (APAP; 1 g every 6 hours) for seven days, followed by three days of placebo. Eleven subjects received only placebo. After five days, 12 subjects (30%) had increases in serum alanine aminotransferase (ALT) levels ("respo ...[more]
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