Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Sahra I
PROVIDER: S-EPMC4786372 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Science (New York, N.Y.) 20160201 6274
In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1) stimulates anabolic processes underlying cell growth. We found that mTORC1 increases metabolic flux through the de novo purine synthesis pathway in various mouse and human cells, thereby influencing the nucleotide pool available for nucleic acid synthesis. mTORC1 had transcriptional effects on multiple enzymes contributing to purine synthesis, with expression of the mitochondrial tetrahydrofolate (mTHF) cycle enzym ...[more]