Dataset Information

Enhanced spontaneous functional connectivity of the superior temporal gyrus in early deafness.

ABSTRACT: Early auditory deprivation may drive the auditory cortex into cross-modal processing of non-auditory sensory information. In a recent study, we had shown that early deaf subjects exhibited increased activation in the superior temporal gyrus (STG) bilaterally during visual spatial working memory; however, the changes in the organization of the STG related spontaneous functional network, and their cognitive relevance are still unknown. To clarify this issue, we applied resting state functional magnetic resonance imaging on 42 early deafness (ED) and 40 hearing controls (HC). We also acquired the visual spatial and numerical n-back working memory (WM) information in these subjects. Compared with hearing subjects, the ED exhibited faster reaction time of visual WM tasks in both spatial and numerical domains. Furthermore, ED subjects exhibited significantly increased functional connectivity between the STG (especially of the right hemisphere) and bilateral anterior insula and dorsal anterior cingulated cortex. Finally, the functional connectivity of STG could predict visual spatial WM performance, even after controlling for numerical WM performance. Our findings suggest that early auditory deprivation can strengthen the spontaneous functional connectivity of STG, which may contribute to the cross-modal involvement of this region in visual working memory.

SUBMITTER: Ding H

PROVIDER: S-EPMC4794647 | biostudies-other | 2016 Mar

REPOSITORIES: biostudies-other

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Enhanced spontaneous functional connectivity of the superior temporal gyrus in early deafness.

Ding Hao H Ming Dong D Wan Baikun B Li Qiang Q Qin Wen W Yu Chunshui C

Scientific reports 20160317

Early auditory deprivation may drive the auditory cortex into cross-modal processing of non-auditory sensory information. In a recent study, we had shown that early deaf subjects exhibited increased activation in the superior temporal gyrus (STG) bilaterally during visual spatial working memory; however, the changes in the organization of the STG related spontaneous functional network, and their cognitive relevance are still unknown. To clarify this issue, we applied resting state functional mag ...[more]

PMID: 26984611

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Project description:Background: Numerous studies have demonstrated that individuals exhibit structured neural activity in many brain regions during rest that is also observed during different tasks, however it is still not clear whether and how resting state activity patterns may relate to underlying tuning for specific stimuli. In the posterior superior temporal gyrus (STG), distinct neural activity patterns are observed during the perception of specific linguistic speech features. We hypothesized that spontaneous resting-state neural dynamics of the STG would be structured to reflect its role in speech perception, exhibiting an organization along speech features as seen during speech perception. Methods: Human cortical local field potentials were recorded from the superior temporal gyrus (STG) in 8 patients undergoing surgical treatment of epilepsy. Signals were recorded during speech perception and rest. Patterns of neural activity (high gamma power: 70-150 Hz) during rest, extracted with spatiotemporal principal component analysis, were compared to spatiotemporal neural responses to speech features during perception. Hierarchical clustering was applied to look for patterns in rest that corresponded to speech feature tuning. Results: Significant correlations were found between neural responses to speech features (sentence onsets, consonants, and vowels) and the spontaneous neural activity in the STG. Across subjects, these correlations clustered into five groups, demonstrating tuning for speech features-most robustly for acoustic onsets. These correlations were not seen in other brain areas, or during motor and spectrally-rotated speech control tasks. Conclusions: In this study, we present evidence that the RS structure of STG activity robustly recapitulates its stimulus-evoked response to acoustic onsets. Further, secondary patterns in RS activity appear to correlate with stimulus-evoked responses to speech features. The role of these spontaneous spatiotemporal activity patterns remains to be elucidated.

Dataset Information

Enhanced spontaneous functional connectivity of the superior temporal gyrus in early deafness.

Publications

Enhanced spontaneous functional connectivity of the superior temporal gyrus in early deafness.

Similar Datasets

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