Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi K
PROVIDER: S-EPMC4796892 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Hayashi Keiichiro K Michiue Hiroyuki H Yamada Hiroshi H Takata Katsuyoshi K Nakayama Hiroki H Wei Fan-Yan FY Fujimura Atsushi A Tazawa Hiroshi H Asai Akira A Ogo Naohisa N Miyachi Hiroyuki H Nishiki Tei-ichi T Tomizawa Kazuhito K Takei Kohji K Matsui Hideki H
Scientific reports 20160318
Glioblastoma multiforme (GBM) is the most common malignant brain tumor with a median survival time about one year. Invasion of GBM cells into normal brain is the major cause of poor prognosis and requires dynamic reorganization of the actin cytoskeleton, which includes lamellipodial protrusions, focal adhesions, and stress fibers at the leading edge of GBM. Therefore, we hypothesized that inhibitors of actin polymerization can suppress GBM migration and invasion. First, we adopted a drug reposit ...[more]