Ontology highlight
ABSTRACT:
SUBMITTER: Glas J
PROVIDER: S-EPMC4797261 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Glas Julia J Dümcke Sebastian S Zacher Benedikt B Poron Don D Gagneur Julien J Tresch Achim A
Nucleic acids research 20151117 5
Hidden Markov models (HMMs) have been extensively used to dissect the genome into functionally distinct regions using data such as RNA expression or DNA binding measurements. It is a challenge to disentangle processes occurring on complementary strands of the same genomic region. We present the double-stranded HMM (dsHMM), a model for the strand-specific analysis of genomic processes. We applied dsHMM to yeast using strand specific transcription data, nucleosome data, and protein binding data fo ...[more]