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Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.


ABSTRACT: Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in the local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements are dependent on the alpha-1 adrenergic receptor and are not observed in IP3R2 (inositol trisphosphate receptor type 2) knockout mice, in which astrocytic Ca(2+) surges are absent. Together, we propose that tDCS changes the metaplasticity of the cortex through astrocytic Ca(2+)/IP3 signalling.

SUBMITTER: Monai H 

PROVIDER: S-EPMC4804173 | biostudies-other | 2016

REPOSITORIES: biostudies-other

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Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.

Monai Hiromu H   Ohkura Masamichi M   Tanaka Mika M   Oe Yuki Y   Konno Ayumu A   Hirai Hirokazu H   Mikoshiba Katsuhiko K   Itohara Shigeyoshi S   Nakai Junichi J   Iwai Youichi Y   Hirase Hajime H  

Nature communications 20160322


Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in the  ...[more]

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