Ontology highlight
ABSTRACT:
SUBMITTER: Monai H
PROVIDER: S-EPMC4804173 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Monai Hiromu H Ohkura Masamichi M Tanaka Mika M Oe Yuki Y Konno Ayumu A Hirai Hirokazu H Mikoshiba Katsuhiko K Itohara Shigeyoshi S Nakai Junichi J Iwai Youichi Y Hirase Hajime H
Nature communications 20160322
Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in the ...[more]