Ontology highlight
ABSTRACT:
SUBMITTER: Akincilar SC
PROVIDER: S-EPMC4805692 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Akincilar Semih Can SC Unal Bilal B Tergaonkar Vinay V
Cellular and molecular life sciences : CMLS 20160204 8
Activation of telomerase is a critical step in the development of about 85 % of human cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are limiting in normal somatic cells. Tert is subjected to transcriptional, post-transcriptional and epigenetic regulation, but the precise mechanism of how telomerase is re-activated in cancer cells is poorly understood. Reactivation of the Tert promoter involves multiple changes which evolve during cancer progression inclu ...[more]