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In vitro comparative assessment of the mechanical properties of PMMA cement and a GPC cement for vertebroplasty.

ABSTRACT: To develop a Glass Polyalkenoate Cement that is suitable for vertebroplasty.Testing was carried out to assess the effect of gamma irradiation used for sterilisation, on the glass transition temperature as well as its mechanical properties, including compressive strength and biflexural strength in vivo as well as testing GPC and PMMA cements post injection in cadaveric human vertebral bone.There was a trend to a higher failure load required for the GPC cement group compared to the current standard PMMA injected group but this was not statistically significant with this small sample size.The results are encouraging for future research to continue on GPC cements for use in vertebroplasty.

SUBMITTER: Abouazza OA

PROVIDER: S-EPMC4805853 | biostudies-other | 2016 Jun

REPOSITORIES: biostudies-other

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In vitro comparative assessment of the mechanical properties of PMMA cement and a GPC cement for vertebroplasty.

Abouazza Omar Ali OA Condon Finbarr F Hannigan Ailish A Dunne Colum C

Journal of orthopaedics 20160223 2

<h4>Aims</h4>To develop a Glass Polyalkenoate Cement that is suitable for vertebroplasty.<h4>Methods</h4>Testing was carried out to assess the effect of gamma irradiation used for sterilisation, on the glass transition temperature as well as its mechanical properties, including compressive strength and biflexural strength in vivo as well as testing GPC and PMMA cements post injection in cadaveric human vertebral bone.<h4>Results</h4>There was a trend to a higher failure load required for the GPC ...[more]

PMID: 27053838

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Project description:PMMA is the most common bone substitute used for vertebroplasty. An increased fracture rate of the adjacent vertebrae has been observed after vertebroplasty. Decreased failure strength has been noted in a laboratory study of augmented functional spine units (FSUs), where the adjacent, non-augmented vertebral body always failed. This may provide evidence that rigid cement augmentation may facilitate the subsequent collapse of the adjacent vertebrae. The purpose of this study was to evaluate whether the decrease in failure strength of augmented FSUs can be avoided using low-modulus PMMA bone cement. In cadaveric FSUs, overall stiffness, failure strength and stiffness of the two vertebral bodies were determined under compression for both the treated and untreated specimens. Augmentation was performed on the caudal vertebrae with either regular or low-modulus PMMA. Endplate and wedge-shaped fractures occurred in the cranial and caudal vertebrae in the ratios endplate:wedge (cranial:caudal): 3:8 (5:6), 4:7 (7:4) and 10:1 (10:1) for control, low-modulus and regular cement group, respectively. The mean failure strength was 3.3 +/- 1 MPa with low-modulus cement, 2.9 +/- 1.2 MPa with regular cement and 3.6 +/- 1.3 MPa for the control group. Differences between the groups were not significant (p = 0.754 and p = 0.375, respectively, for low-modulus cement vs. control and regular cement vs. control). Overall FSU stiffness was not significantly affected by augmentation. Significant differences were observed for the stiffness differences of the cranial to the caudal vertebral body for the regular PMMA group to the other groups (p < 0.003). The individual vertebral stiffness values clearly showed the stiffening effect of the regular cement and the lesser alteration of the stiffness of the augmented vertebrae using the low-modulus PMMA compared to the control group (p = 0.999). In vitro biomechanical study and biomechanical evaluation of the hypothesis state that the failure strength of augmented functional spine units could be better preserved using low-modulus PMMA in comparison to regular PMMA cement.

Dataset Information

In vitro comparative assessment of the mechanical properties of PMMA cement and a GPC cement for vertebroplasty.

Publications

In vitro comparative assessment of the mechanical properties of PMMA cement and a GPC cement for vertebroplasty.

Similar Datasets

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