Ontology highlight
ABSTRACT:
SUBMITTER: Segura I
PROVIDER: S-EPMC4805856 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Segura Inmaculada I Lange Christian C Knevels Ellen E Moskalyuk Anastasiya A Pulizzi Rocco R Eelen Guy G Chaze Thibault T Tudor Cicerone C Boulegue Cyril C Holt Matthew M Daelemans Dirk D Matondo Mariette M Ghesquière Bart B Giugliano Michele M Ruiz de Almodovar Carmen C Dewerchin Mieke M Carmeliet Peter P
Cell reports 20160310 11
Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs), and silencing of Phd2 induce immature filopodium-like dendritic protrusions, promote spine regression, reduce synaptic density, and decrease the frequency of spontaneous action potentials independently of HIF signaling. We identified the ...[more]