Amyloid-like ribbons of amelogenins in enamel mineralization.
Ontology highlight
ABSTRACT:
SUBMITTER: Carneiro KM
PROVIDER: S-EPMC4806362 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Publications
Amyloid-like ribbons of amelogenins in enamel mineralization.
Carneiro Karina M M KM Zhai Halei H Zhu Li L Horst Jeremy A JA Sitlin Melody M Nguyen Mychi M Wagner Martin M Simpliciano Cheryl C Milder Melissa M Chen Chun-Long CL Ashby Paul P Bonde Johan J Li Wu W Habelitz Stefan S
Scientific reports 20160324
Enamel, the outermost layer of teeth, is an acellular mineralized tissue that cannot regenerate; the mature tissue is composed of high aspect ratio apatite nanocrystals organized into rods and inter-rod regions. Amelogenin constitutes 90% of the protein matrix in developing enamel and plays a central role in guiding the hierarchical organization of apatite crystals observed in mature enamel. To date, a convincing link between amelogenin supramolecular structures and mature enamel has yet to be d ...[more]
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