Ontology highlight
ABSTRACT:
SUBMITTER: Mikkers H
PROVIDER: S-EPMC480904 | biostudies-other | 2004 Jul
REPOSITORIES: biostudies-other
Mikkers Harald H Nawijn Martijn M Allen John J Brouwers Conny C Verhoeven Els E Jonkers Jos J Berns Anton A
Molecular and cellular biology 20040701 13
The Pim family of proto-oncogenes encodes a distinct class of serine/threonine kinases consisting of PIM1, PIM2, and PIM3. Although the Pim genes are evolutionarily highly conserved, the contribution of PIM proteins to mammalian development is unclear. PIM1-deficient mice were previously described but showed only minor phenotypic aberrations. To assess the role of PIM proteins in mammalian physiology, compound Pim knockout mice were generated. Mice lacking expression of Pim1, Pim2, and Pim3 are ...[more]