Unknown

Dataset Information

0

Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation.


ABSTRACT: Objective This study aims to examine the relationship between antenatal magnesium sulfate (MgSO4) and neonatal death and/or severe necrotizing enterocolitis (NEC) among infants < 28 weeks. Methods Secondary analysis of a multicenter randomized trial of antenatal MgSO4 versus placebo administered to women to prevent death and cerebral palsy. Neonates < 28 weeks were included. The primary outcome was neonatal death before NICU discharge, and/or severe NEC (Bell criteria stage II/III). Neonates with and without death/severe NEC were compared. Results A total of 697 neonates met the criteria. Out of which 150 (21.5%) died and/or were diagnosed with severe NEC. Antenatal MgSO4 exposure was not associated with death/severe NEC in infants < 28 weeks. In a subgroup analysis of neonates < 26 weeks, treatment group assignment to antenatal MgSO4 was associated with an increased odds of death/severe NEC (adjusted odds ratio: 1.90, 95% confidence interval: 1.12-3.22, p = 0.017). Conclusions Among neonates < 26 weeks, antenatal MgSO4 was associated with death and severe NEC. Further prospective study in larger populations is needed.

SUBMITTER: Kamyar M 

PROVIDER: S-EPMC4816636 | biostudies-other | 2016 Mar

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC7995678 | biostudies-literature
2013-08-21 | E-GEOD-48125 | biostudies-arrayexpress
| S-EPMC7614399 | biostudies-literature
| S-EPMC3761983 | biostudies-literature
| S-EPMC3094198 | biostudies-literature
| S-EPMC5560643 | biostudies-literature
| S-EPMC8277891 | biostudies-literature
2018-05-22 | GSE114705 | GEO
2013-08-21 | GSE48125 | GEO
| S-EPMC5777619 | biostudies-other