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Data on skeletal muscle apoptosis, autophagy, and morphology in mice treated with doxorubicin.


ABSTRACT: Skeletal muscle apoptosis and autophagy are catabolic processes that contribute to muscle atrophy during aging, disease, and following muscle injury. In this article, we present data on skeletal muscle apoptosis, autophagy, and morphology in C57BL/6 mice following doxorubicin administration. More specifically, time-course data on caspase-3, caspase-8, caspase-9, calpain, and cathepsin activity are presented, along with data on ATG7, p62, LC3-I, and LC3-II protein expression. Data on skeletal muscle reactive oxygen species (ROS) production, muscle morphology, as well as body and muscle weights are also presented.

SUBMITTER: Campbell TL 

PROVIDER: S-EPMC4816877 | biostudies-other | 2016 Jun

REPOSITORIES: biostudies-other

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Data on skeletal muscle apoptosis, autophagy, and morphology in mice treated with doxorubicin.

Campbell Troy L TL   Quadrilatero Joe J  

Data in brief 20160310


Skeletal muscle apoptosis and autophagy are catabolic processes that contribute to muscle atrophy during aging, disease, and following muscle injury. In this article, we present data on skeletal muscle apoptosis, autophagy, and morphology in C57BL/6 mice following doxorubicin administration. More specifically, time-course data on caspase-3, caspase-8, caspase-9, calpain, and cathepsin activity are presented, along with data on ATG7, p62, LC3-I, and LC3-II protein expression. Data on skeletal mus  ...[more]

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