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New strategies against drug resistance to herpes simplex virus.

ABSTRACT: Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.

SUBMITTER: Jiang YC

PROVIDER: S-EPMC4822185 | biostudies-other | 2016 Mar

REPOSITORIES: biostudies-other

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New strategies against drug resistance to herpes simplex virus.

Jiang Yu-Chen YC Feng Hui H Lin Yu-Chun YC Guo Xiu-Rong XR

International journal of oral science 20160330 1

Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistanc ...[more]

PMID: 27025259

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