Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4822413 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Zhang Yongchun Y Sheu Tzong-jen TJ Hoak Donna D Shen Jie J Hilton Matthew J MJ Zuscik Michael J MJ Jonason Jennifer H JH O'Keefe Regis J RJ
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20160301 3
WNT/β-CATENIN signaling is involved in multiple aspects of skeletal development, including chondrocyte differentiation and maturation. Although the functions of β-CATENIN in chondrocytes have been extensively investigated through gain-of-function and loss-of-function mouse models, the precise downstream effectors through which β-CATENIN regulates these processes are not well defined. Here, we report that the matricellular protein, CCN1, is induced by WNT/β-CATENIN signaling in chondrocytes. Spec ...[more]