Ontology highlight
ABSTRACT:
SUBMITTER: Abdelbaset-Ismail A
PROVIDER: S-EPMC4823088 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Oncotarget 20160101 3
We recently reported that normal hematopoietic stem cells express functional pituitary sex hormone (SexH) receptors. Here we report for the first time that pituitary-secreted gonadotrophins stimulate migration, adhesion, and proliferation of several human myeloid and lymphoid leukemia cell lines. Similar effects were observed after stimulation of human leukemic cell lines by gonadal SexHs. This effect seems to be direct, as the SexH receptors expressed by leukemic cells responded to stimulation ...[more]