Ontology highlight
ABSTRACT:
SUBMITTER: De Marco P
PROVIDER: S-EPMC4829876 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Scientific reports 20160413
Cancer-associated fibroblasts (CAFs) contribute to the malignant aggressiveness through secreted factors like IL1β, which may drive pro-tumorigenic inflammatory phenotypes mainly acting via the cognate receptor named IL1R1. Here, we demonstrate that signalling mediated by the G protein estrogen receptor (GPER) triggers IL1β and IL1R1 expression in CAFs and breast cancer cells, respectively. Thereby, ligand-activation of GPER generates a feedforward loop coupling IL1β induction by CAFs to IL1R1 e ...[more]