Ontology highlight
ABSTRACT:
SUBMITTER: Lissek T
PROVIDER: S-EPMC4830828 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Frontiers in cellular neuroscience 20160414
General anesthetics are commonly used in animal models to study how sensory signals are represented in the brain. Here, we used two-photon (2P) calcium activity imaging with cellular resolution to investigate how neuronal activity in layer 2/3 of the mouse barrel cortex is modified under the influence of different concentrations of chemically distinct general anesthetics. Our results show that a high isoflurane dose induces synchrony in local neuronal networks and these cortical activity pattern ...[more]