Unknown

Dataset Information

0

Lysine fatty acylation promotes lysosomal targeting of TNF-α.


ABSTRACT: Tumor necrosis factor-α (TNF-α) is a proinflammation cytokine secreted by various cells. Understanding its secretive pathway is important to understand the biological functions of TNF-α and diseases associated with TNF-α. TNF-α is one of the first proteins known be modified by lysine fatty acylation (e.g. myristoylation). We previously demonstrated that SIRT6, a member of the mammalian sirtuin family of enzymes, can remove the fatty acyl modification on TNF-α and promote its secretion. However, the mechanistic details about how lysine fatty acylation regulates TNF-α secretion have been unknown. Here we present experimental data supporting that lysine fatty acylation promotes lysosomal targeting of TNF-α. The result is an important first step toward understanding the biological functions of lysine fatty acylation.

SUBMITTER: Jiang H 

PROVIDER: S-EPMC4832147 | biostudies-other | 2016 Apr

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6452895 | biostudies-literature
| S-EPMC9352737 | biostudies-literature
| S-EPMC3635073 | biostudies-literature
| S-EPMC8339906 | biostudies-literature
| S-EPMC5745086 | biostudies-literature
| S-EPMC8851525 | biostudies-literature
| S-EPMC6893912 | biostudies-literature
| S-EPMC1948971 | biostudies-other
| S-EPMC9061198 | biostudies-literature
| S-EPMC7790989 | biostudies-literature