Ontology highlight
ABSTRACT:
SUBMITTER: Broecker F
PROVIDER: S-EPMC4838876 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Broecker Felix F Hanske Jonas J Martin Christopher E CE Baek Ju Yuel JY Wahlbrink Annette A Wojcik Felix F Hartmann Laura L Rademacher Christoph C Anish Chakkumkal C Seeberger Peter H PH
Nature communications 20160419
Synthetic cell-surface glycans are promising vaccine candidates against Clostridium difficile. The complexity of large, highly antigenic and immunogenic glycans is a synthetic challenge. Less complex antigens providing similar immune responses are desirable for vaccine development. Based on molecular-level glycan-antibody interaction analyses, we here demonstrate that the C. difficile surface polysaccharide-I (PS-I) can be resembled by multivalent display of minimal disaccharide epitopes on a sy ...[more]