Dataset Information

Long-term accelerometry-triggered video monitoring and detection of tonic-clonic and clonic seizures in a home environment: Pilot study.

ABSTRACT: The aim of our study was to test the efficacy of the VARIA system (video, accelerometry, and radar-induced activity recording) and validation of accelerometry-based detection algorithms for nocturnal tonic-clonic and clonic seizures developed by our team.We present the results of two patients with tonic-clonic and clonic seizures, measured for about one month in a home environment with four wireless accelerometers (ACM) attached to wrists and ankles. The algorithms were developed using wired ACM data synchronized with the gold standard video-/electroencephalography (EEG) and then run offline on the wireless ACM signals. Detection of seizures was compared with semicontinuous monitoring by professional caregivers (keeping an eye on multiple patients).The best result for the two patients was obtained with the semipatient-specific algorithm which was developed using all patients with tonic-clonic and clonic seizures in our database with wired ACM. It gave a mean sensitivity of 66.87% and false detection rate of 1.16 per night. This included 13 extra seizures detected (31%) compared with professional caregivers' observations.While the algorithms were previously validated in a controlled video/EEG monitoring unit with wired sensors, we now show the first results of long-term, wireless testing in a home environment.

SUBMITTER: Van de Vel A

PROVIDER: S-EPMC4840430 | biostudies-other | 2016

REPOSITORIES: biostudies-other

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Publications

Long-term accelerometry-triggered video monitoring and detection of tonic-clonic and clonic seizures in a home environment: Pilot study.

Van de Vel Anouk A Milosevic Milica M Bonroy Bert B Cuppens Kris K Lagae Lieven L Vanrumste Bart B Van Huffel Sabine S Ceulemans Berten B

Epilepsy & behavior case reports 20160406

<h4>Purpose</h4>The aim of our study was to test the efficacy of the VARIA system (video, accelerometry, and radar-induced activity recording) and validation of accelerometry-based detection algorithms for nocturnal tonic-clonic and clonic seizures developed by our team.<h4>Methods</h4>We present the results of two patients with tonic-clonic and clonic seizures, measured for about one month in a home environment with four wireless accelerometers (ACM) attached to wrists and ankles. The algorithm ...[more]

PMID: 27144123

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Project description:PURPOSE:To provide an estimate of the frequency of dacrystic seizures in video-electroencephalography (EEG) long-term monitoring units of tertiary referral epilepsy centers and to describe the clinical presentation of dacrystic seizures in relationship to the underlying etiology. METHODS:We screened clinical records and video-EEG reports for the diagnosis of dacrystic seizures of all patients admitted for video-EEG long-term monitoring at five epilepsy referral centers in the United States and Germany. Patients with a potential diagnosis of dacrystic seizures were identified, and their clinical charts and video-EEG recordings were reviewed. We included only patients with: (1) stereotyped lacrimation, sobbing, grimacing, yelling, or sad facial expression; (2) long-term video-EEG recordings (at least 12 h); and (3) at least one brain magnetic resonance imaging (MRI) study. KEY FINDINGS:Nine patients (four female) with dacrystic seizures were identified. Dacrystic seizures were identified in 0.06-0.53% of the patients admitted for long-term video-EEG monitoring depending on the specific center. Considering our study population as a whole, the frequency was 0.13%. The presence of dacrystic seizures without other accompanying clinical features was found in only one patient. Gelastic seizures accompanied dacrystic seizures in five cases, and a hypothalamic hamartoma was found in all of these five patients. The underlying etiology in the four patients with dacrystic seizures without gelastic seizures was left mesial temporal sclerosis (three patients) and a frontal glioblastoma (one patient). All patients had a difficult-to-control epilepsy as demonstrated by the following: (1) at least three different antiepileptic drugs were tried in each patient, (2) epilepsy was well controlled with antiepileptic drugs in only two patients, (3) six patients were considered for epilepsy surgery and three of them underwent a surgical/radiosurgical or radioablative procedure. Regarding outcome, antiepileptic drugs alone achieved seizure freedom in two patients and did not change seizure frequency in another patient. Radiosurgery led to moderately good seizure control in one patient and did not improve seizure control in another patient. Three patients were or are being considered for epilepsy surgery on last follow-up. One patient remains seizure free 3 years after epilepsy surgery. SIGNIFICANCE:Dacrystic seizures are a rare but clinically relevant finding during video-EEG monitoring. Our data show that when the patient has dacrystic and gelastic seizures, the cause is a hypothalamic hamartoma. In contrast, when dacrystic seizures are not accompanied by gelastic seizures the underlying lesion is most commonly located in the temporal cortex.

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Dataset Information

Long-term accelerometry-triggered video monitoring and detection of tonic-clonic and clonic seizures in a home environment: Pilot study.

Publications

Long-term accelerometry-triggered video monitoring and detection of tonic-clonic and clonic seizures in a home environment: Pilot study.

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