Dataset Information

Temporal Effects of Child and Adolescent Exposure to Neighborhood Disadvantage on Black/White Disparities in Young Adult Obesity.

ABSTRACT: This study investigates the effects of duration and timing of exposure to neighborhood disadvantage from birth through age 17 years on obesity incidence in early adulthood and black/white disparities therein.Individual- and household-level data from the 1970-2011 waves of the Panel Study of Income Dynamics are merged with census data on respondents' neighborhoods (n = 1,498). Marginal structural models with inverse probability of treatment and censoring weights are used to quantify the probability of being obese at least once between ages 18 and 30 years as a function of cumulative exposure to neighborhood disadvantage throughout childhood and adolescence or during each of three developmental stages therein.Longer term exposure to neighborhood disadvantage from ages 0-17 years is more common among blacks than among whites and is associated with significantly greater odds of being obese at least once in early adulthood. Exposure to neighborhood-level deprivation during adolescence (ages 10-17 years) appears more consequential for future (young adult) obesity than exposure that occurs earlier in childhood.The duration and timing of exposure to neighborhood disadvantage during childhood and adolescence are associated with obesity incidence in early adulthood for both blacks and whites. However, given inequalities in the likelihood and persistence of experiencing neighborhood disadvantage as children and youth, such adverse effects are likely to be more concentrated among black versus white young adults.

SUBMITTER: Kravitz-Wirtz N

PROVIDER: S-EPMC4842347 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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Publications

Temporal Effects of Child and Adolescent Exposure to Neighborhood Disadvantage on Black/White Disparities in Young Adult Obesity.

Kravitz-Wirtz Nicole N

The Journal of adolescent health : official publication of the Society for Adolescent Medicine 20160316 5

<h4>Purpose</h4>This study investigates the effects of duration and timing of exposure to neighborhood disadvantage from birth through age 17 years on obesity incidence in early adulthood and black/white disparities therein.<h4>Methods</h4>Individual- and household-level data from the 1970-2011 waves of the Panel Study of Income Dynamics are merged with census data on respondents' neighborhoods (n = 1,498). Marginal structural models with inverse probability of treatment and censoring weights ar ...[more]

PMID: 26995292

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Project description:Neighborhood disadvantage and community violence are common in poor, urban communities and are risk factors for emotional dysfunction. Emotional processes are supported by neural circuitry that includes the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, stria terminalis, and fornix. Emotional function varies with the microstructure of these white matter pathways. However, it is not clear whether the microstructure of these pathways varies with risk factors for emotional dysfunction (e.g., neighborhood disadvantage and violence exposure). Therefore, determining the relationships between neighborhood disadvantage, violence exposure, and white matter microstructure may offer insight into the neural mechanisms by which adverse life experiences alter developing neural systems. The current study investigated the association that exposure to neighborhood disadvantage and violence have with the quantitative anisotropy (QA), a measure of the amount of directional water diffusion, of the cingulum bundle, uncinate fasciculus, stria terminalis, and fornix. Neighborhood disadvantage (Mage = 11.20) and violence exposure (MW1age = 11.20; MW2age = 13.05; MW3age = 16.20; MW4age = 19.25) were assessed during adolescence and participants returned for magnetic resonance imaging as young adults (N = 303; Mage = 20.25, SD = 1.55), during which diffusion weighted brain images were collected. The QA of the cingulum bundle, uncinate fasciculus, and stria terminalis/fornix varied negatively with neighborhood disadvantage such that the QA of these white matter tracts decreased as neighborhood disadvantage increased. Violence exposure was not related to QA in any tract (i.e., cingulum bundle, uncinate fasciculus, and stria terminalis/fornix) after correction for multiple comparisons. These results suggest that an adolescent's neighborhood may play an important role in the microstructure (i.e., QA) of white matter pathways that connect brain regions that support emotional function.

Project description:Racial disparities in many aging-related health outcomes are persistent and pervasive among older Americans, reflecting accelerated biological aging for Black Americans compared to White, known as weathering. Environmental determinants that contribute to weathering are poorly understood. Having a higher biological age, measured by DNA methylation (DNAm), than chronological age is robustly associated with worse age-related outcomes and higher social adversity. We hypothesize that individual socioeconomic status (SES), neighborhood social environment, and air pollution exposures contribute to racial disparities in DNAm aging according to GrimAge and Dunedin Pace of Aging methylation (DPoAm). We perform retrospective cross-sectional analyses among 2,960 non-Hispanic participants (82% White, 18% Black) in the Health and Retirement Study whose 2016 DNAm age is linked to survey responses and geographic data. DNAm aging is defined as the residual after regressing DNAm age on chronological age. We observe Black individuals have significantly accelerated DNAm aging on average compared to White individuals according to GrimAge (239%) and DPoAm (238%). We implement multivariable linear regression models and threefold decomposition to identify exposures that contribute to this disparity. Exposure measures include individual-level SES, census-tract-level socioeconomic deprivation and air pollution (fine particulate matter, nitrogen dioxide, and ozone), and perceived neighborhood social and physical disorder. Race and gender are included as covariates. Regression and decomposition results show that individual-level SES is strongly associated with and accounts for a large portion of the disparity in both GrimAge and DPoAm aging. Higher neighborhood deprivation for Black participants significantly contributes to the disparity in GrimAge aging. Black participants are more vulnerable to fine particulate matter exposure for DPoAm, perhaps due to individual- and neighborhood-level SES, which may contribute to the disparity in DPoAm aging. DNAm aging may play a role in the environment "getting under the skin", contributing to age-related health disparities between older Black and White Americans.

Dataset Information

Temporal Effects of Child and Adolescent Exposure to Neighborhood Disadvantage on Black/White Disparities in Young Adult Obesity.

Publications

Temporal Effects of Child and Adolescent Exposure to Neighborhood Disadvantage on Black/White Disparities in Young Adult Obesity.

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