Enhanced User-Control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tethers.

ABSTRACT: We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a ?-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleratation of the release rate of an entrapped model drug.

SUBMITTER: Nehls EM 

PROVIDER: S-EPMC4843523 | biostudies-other | 2016

REPOSITORIES: biostudies-other