Ontology highlight
ABSTRACT:
SUBMITTER: Zhang CH
PROVIDER: S-EPMC4844698 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Zhang Cheng-Hai CH Wang Pei P Liu Dong-Hai DH Chen Cai-Ping CP Zhao Wei W Chen Xin X Chen Chen C He Wei-Qi WQ Qiao Yan-Ning YN Tao Tao T Sun Jie J Peng Ya-Jing YJ Lu Ping P Zheng Kaizhi K Craige Siobhan M SM Lifshitz Lawrence M LM Keaney John F JF Fogarty Kevin E KE ZhuGe Ronghua R Zhu Min-Sheng MS
Nature communications 20160422
Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal incontinence. However, the molecular mechanisms underlying this tone remain unknown. Here, we show that deletion of myosin light-chain kinases (MLCK) in the smooth muscle cells from internal anal sphincter (IAS-SMCs) abolishes basal tone, impairing defecation. Pharmacological regulation of ryanodine receptors (RyRs), L- ...[more]