Model organoids provide new research opportunities for ductal pancreatic cancer.

ABSTRACT: We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

SUBMITTER: Boj SF 

PROVIDER: S-EPMC4845167 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other